|
KMID : 1130620180140010073
|
|
Journal of Clinical Neurology
2018 Volume.14 No. 1 p.73 ~ p.80
|
|
|
Partial Conduction Block as an Early Nerve Conduction Finding in Neurolymphomatosis
|
|
Park Hyung-Jun
Shin Ha-Young
Kim Se-Hoon
Jeong Ha-Neul
Choi Young-Chul
Suh Bum-Chun
Park Kee-Duk
Kim Seung-Min
|
|
|
Abstract
|
|
|
Background and Purpose: Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis.
Methods: We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54%) of the patients were men, and the median age at symptom onset was 60.0 years.
Results: The most common type of underlying malignancy was diffuse large B-cell lymphoma (69%). Twelve patients had painful asymmetric neuropathies. The median survival time after diagnosis was 7 months, and 12 patients died during the study period. Thirty-eight motor nerve conduction studies (NCSs) were performed in the affected nerves. Ten and 28 motor nerves were classified into the conduction-block and simple-axon-degeneration groups, respectively. The median time interval between symptom onset and the NCS was significantly shorter in the conduction-block group than in the simple-axon-degeneration group (p=0.032). However, no significant differences in the motor nerve conduction velocities, terminal latencies, and distal compound muscle action potential amplitudes were identified between the conduction-block and simple-axon-degeneration groups. The conduction-block group showed excessive temporal dispersion in only five of the ten NCSs (50%). Follow-up NCSs revealed that partial conduction blocks had changed into axonal degeneration patterns.
Conclusions: This is the first study to analyze the electrophysiological features of patients with neurolymphomatosis. Our findings showed that a partial conduction block is not rare and is an early nerve conduction abnormality in neurolymphomatosis.
|
|
|
KEYWORD
|
|
|
neurolymphomatosis, lymphoma, leukemia, nerve conduction study, conduction block
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|